With the Fierce Business Development and Licensing Summit for Life Sciences scheduled for mid-March, ResoluteAI examined the licensing and partnership activity of some of the pharmaceutical and life sciences companies planning to attend. Our first post covers Eli Lilly.
Licensing and partnership activity
Eli Lilly has a long history of licensing and partnership activity. The network graph below shows several co-patents with companies like Elan Pharmaceuticals, Ligand Pharmaceuticals, and Athena Neurosciences.
Network graph of Eli Lilly's co-patents by company name and tags (research area)
Eli Lilly has also partnered with and invested in many smaller pharma and biotech companies, as can be seen in the news network graph below, with data courtesy of FinTech Studios.
Network graph of pharma and biotech companies Eli Lilly has partnered with or invested in
A partnership for antibody drug-conjugates
One of their latest partnerships involves ImmunoGen, a small biotech firm focused on cancer therapeutics. ImmunoGen recently announced a long-term licensing deal with the pharmaceutical giant, securing an initial payment of $13 million. ImmunoGen’s primary technology, antibody drug-conjugates or ADCs, have been growing in viability over the past several decades, as researchers sought to lower the unintended toxicity brought upon healthy cells from systemic chemotherapy treatments. Exiting 2021 with $28B in revenue, Eli Lilly’s current investment in ImmunoGen further supports the potential shift to more selectively targeted cancer cell treatments. Ultimately, ImmunoGen could earn up to $1.5 billion from the deal.
While research into ADCs has been ongoing for decades, market size is expected to grow significantly. By pairing a chemotherapy agent with an antibody receptive to tumor cell antigens, the potential to increase cancer treatment efficacy and reduce harmful side effects is enormous. As such, a search of global clinical trial databases demonstrates that the amount of trials being initiated has steadily increased over the past several years. By exporting results from ResoluteAI’s Drugs module, we see that there are a handful of ADCs available for several different cancer types.
Number of ADC clinical trials by start year
Currently available ADCs
|Brand name||Generic name||Manufacturers name|
|Tivdak||Tisotumab Vedotin||Seagen Inc.|
|Mylotarg||Gemtuzumab Ozogamicin||Wyeth Pharmaceuticals LLC a subsidiary of Pfizer Inc|
|Padcev Ejfv||Enfortumab Vedotin||Seagen Inc.|
|Adcetris||Brentuximab Vedotin||Seagen Inc.|
|Enhertu||Fam-Trastuzumab Deruxtecan-Nxki||Daiichi Sankyo Inc.|
|Kadcyla||Ado-Trastuzumab Emtansine||Genentech Inc.|
|Polivy||Polatuzumab Vedotin||Genentech Inc.|
|Besponsa||Inotuzumab Ozogamicin||Wyeth Pharmaceuticals LLC a subsidiary of Pfizer Inc|
A partnership for metabolic disorders
In addition to ImmunoGen, Eli Lilly recently struck another licensing deal with Shanghai-based Regor Therapeutics. Founded in 2018, Regor Therapeutics closed out their February 2021 Series B round with $90 million, fully funded by Chinese VC firms. As the Sankey diagram shows, Eli Lilly is the first major American pharmaceutical corporation to financially back the company.
Companies funding Regor Therapeutics
Eli Lilly’s initial investment of $50 million in Regor Therapeutics will support the development of treatments for metabolic disorders. Eli Lilly will also lead the sales of these drugs in most international markets, complementing their robust portfolio of competitive diabetes drugs. Of the eight patents Regor Therapeutics currently has, four represent compounds intended for use in treatments for a set of associated metabolic dysfunctions: obesity, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, prediabetes, diabetes, and cardiovascular disease. These conditions are highlighted in the network graph blow, among the other relevant tags and categories for these patents.
Network graph of Regor Therapeutics patents by category (pink) and research area (blue)
This information was discovered using Foundation, the scientific discovery engine. For more information on Foundation and ResoluteAI’s analytical tools, please contact us at firstname.lastname@example.org or use the link below.